March Madness 2022: The 10 biggest opening weekend upsets in the NCAA Tournament of all-time | CBS Sports Headlines March Madness 2022: The 10 biggest opening weekend upsets in the NCAA Tournament of all-time This isn’t for just for your No. 12 seeds topping No. 5 seeds, these are games … Continue reading March Madness 2022: The 10 biggest opening weekend upsets in the NCAA Tournament of all-time