49ers vs. Lions odds, line, spread: 2021 NFL picks, Week 1 predictions from proven computer model | CBS Sports Headlines 49ers vs. Lions odds, line, spread: 2021 NFL picks, Week 1 predictions from proven computer model SportsLine’s model just revealed its NFL picks for Lions vs. 49ers ESN FeedsThis post … Continue reading 49ers vs. Lions odds, line, spread: 2021 NFL picks, Week 1 predictions from proven computer model